TFE25-431
MRI biomarkers of success of cochlear implant therapy in patients with acquired deafness
Max student :
1 or 2
Promoters:
Laurence Dricot et Quentin Dessain
Description:
The absence of hearing from birth has major consequences of the development of the grey and white matter of the brain. The aim of the project is to analyze an MRI data-set containing anatomical (MPRAGE) scans of the brain, resting-state functional MRI data (rsfMRI) and diffusion magnetic resonance imaging (dMRI) to assess predictive factors of cochlear implant (CI) therapy in patients with acquired hearing loss. Hearing loss can be adequately treated by cochlear implant therapy. Although the average success rate of CI therapy is quite high, around 30% of the patients the results are insufficient. The purpose of this project is to find predictive magnetic resonance imaging (MRI) markers of therapeutic success of CI: therapy. Patients undergo multimodal MRI (MPRAGE; diffusion imaging, functional MRI) before surgery and outcome of CI therapy is measured at 6 and 12-months CI. We have shown before that measures of cortical grey matter volume can predict CI outcome therapy. The purpose of the master’s project is to use the diffusion imaging data to track some of the auditory fibers in these patients and test whether they predict CI success, and whether the prediction of CI success increases when the diffusion imaging data are combined with brain volumetric measures and/or resting-state fMRI data.
Figure : Preservation of GM volume within the left precuneus, middle and inferior gyri is associated with better audiovisual speech perception after CI